GUIDE does not require an extra license. MATLAB Compiler does, though.
"And will I be able to export applications that can dynamically be controlled by the user in order to generate a simulink-like environments?"
Although that is technically possible, it runs the risk of violating the license terms:
"1. Deployment Rights for User Files
You may distribute or sublicense User Files without restriction, provided that a principal purpose of the distribution or sublicense is not to replace or replicate a Program or any part of a Program and you otherwise comply with the general restrictions of the Software License Agreement and your License Offering."
"iii) Your Application may not provide capability similar to the capabilities of any of Programs, or provide functionality or behavior similar to that of the MATLAB command line or scripting and programming capabilities. Your Application also may not enable evaluation of end-user code or expressions.
iv) Your Application may not provide access to all or a substantial portion of a Program."
